This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of granulocyte-macrophage colony-stimulating factor with or without supervised exercise on walking performance in patients with peripheral artery disease. The PROPEL randomized clinical trial. JAMA 2017; 318: 2089-2098.

Published: 22nd February 2018

Authors: McDermott MM, Ferrucci L, Tian L, Guralnik JM, Lloyd-Jones D, Kibbe MR et al.

Conclusion

Some 210 patients were included in four groups. Supervised exercise alone for twelve weeks improved six minute treadmill walking by 34 m. The addition of GM-CSF did not improve walking distance further. GM-CSF alone had no beneficial effect.

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