This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADE-DB trial): a double-blind randomised study. Lancet Gastroenterol Hepatol 2020; 5: 343-351.

Published: 15th October 2020

Authors: Wang P, Liu X, Berzin TM, Glissen Brown JR, Liu P, Zhou C et al.

Conclusion

The analysis included 962 procedures. Adenoma detection rate was higher in computer-aided procedures: 34 versus 28 per cent, P=0.03. Missed polyps were generally smaller and flatter.

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Cancer prevention with aspirin in hereditary colorectal cancer (Lynch Syndrome), a 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double blind, randomised, placebo-controlled trial. Lancet 2020; 395: 1855-1863.

Authors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin J-P et al.

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Modifiable pathways for colorectal cancer: a mendelian randomisation analysis. Lancet Gastroenterol Hepatol 2020; 5: 142-151

Authors: Cornish AJ, Law PJ, Tomofeeva M, Palin K, Farrington SM, Palles C et al.

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Efficacy and safety of sodium picosulfate/magnesium citrate for bowel preparation in a physically disabled outpatient population: a randomized, endoscopist-blinded comparison with ascorbic acid-enriched polyethylene glycol solution plus bisacodyl (The PICO-MOVI Study). Dis Colon Rectum 2018; 61: 239-249.

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Comparative evaluation of the efficacy of polyethylene glycol with ascorbic acid and an oral sulfate solution in a split method for bowel preparation: a randomized, multicenter phase III clinical trial. Dis Colon Rectum 2017; 60: 426-432.

Authors: Bun K, Lee SD, Han KS, Kim BC, Youk E-G, Nam MJ et al.

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Split-dose preparation for colonoscopy increases adenoma detection rate: a randomised controlled trial in an organised screening programme. Gut 2017; 66: 270-277.

Authors: Paggi S, Hassan C, Senore C, Fasoli R, Anderloni A, Buffoli F et al.

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Celecoxib for the prevention of colorectal adenomas: results of a suspended randomized controlled trial. J Natl Cancer Inst 2016; 108: djw151.

Authors: Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F et al.

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Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia. BMJ 2016; 355: i6188.

Authors: Dulai PS, Singh S, Marquez E, Khera R, Prokop LJ, Limburg PJ et al.

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Real-time optical diagnosis for diminutive colorectal polyps using narrow-band imaging: the VALID randomised clinical trial. Gut 2015; 64: 1569-1577.

Authors: Kaltenbach T, Rastogi A, Rouse RV, McQuaid KR, Sato T, Bansal A et al. et al.

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Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis. Gut 2015; 64: 1419-1425.

Authors: Li P, Wu H, Zhang H, Shi Y, Xu J, Ye Y et al. et al.

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A trial of calcium and vitamin D for the prevention of colorectal adenomas. N Engl J Med 2015; 373: 1519-1530.

Authors: Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, Snover DC et al. et al.

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The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial. Gut 2014; 63: 1755-1759.

Authors: Ishikawa H, Mutoh M, Suzuki S, Tokudome S, Saida Y, Abe T et al. et al.

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Randomized clinical trial comparing reduced-volume oral picosulphate and a prepackaged low-residue diet with 4-liter PEG solution for bowel preparation. Dis Colon Rectum 2014; 57: 522-528.

Authors: Kim Ys, Hong CW, Kim BC, Han KS, Park JW, Seong Choi H et al. et al.