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Effect of early surgery vs endoscopy-first approach on pain in patients with chronic pancreatitis. The ESCAPE randomized clinical trial. JAMA 2020; 323: 237-247

Published: 20th March 2020

Authors: Issa Y, Kempeneers MA, Bruno MJ, Fockens P, Poley J-W, Ali UA et al.


Eighty-eight patients with painful chronic pancreatitis were included and followed for 18 months. Patients randomized to early surgical drainage procedures had less chronic pain (P=0.02). Complete or partial pain relief was experienced by 58 per cent after surgery versus 39 per cent in controls, P=0.01.

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