This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of early surgery vs endoscopy-first approach on pain in patients with chronic pancreatitis. The ESCAPE randomized clinical trial. JAMA 2020; 323: 237-247

Published: 20th March 2020

Authors: Issa Y, Kempeneers MA, Bruno MJ, Fockens P, Poley J-W, Ali UA et al.

Conclusion

Eighty-eight patients with painful chronic pancreatitis were included and followed for 18 months. Patients randomized to early surgical drainage procedures had less chronic pain (P=0.02). Complete or partial pain relief was experienced by 58 per cent after surgery versus 39 per cent in controls, P=0.01.

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