This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial Lancet 2008; 372: 392¿397

Published: 1st January 2008

Authors: Fukase K, Kato M, Kikuchi S, Inoue K, Uemura N, Okamoto S et al et al.

Conclusion

A total of 544 patients were included. After three years, a second cancer developed in 9 patients who had eradication therapy, and 24 controls: odds ratio 0.35, 95 per cent confidence interval 0.16 to 0.77, P=0.009

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Short-term outcomes of robotic gastrectomy vs laparoscopic gastrectomy for patients with gastric cancer. A randomized clinical trial. JAMA Surg 2021; 156: 954-963.

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IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.

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A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

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Assessment of robotic versus laparoscopic distal gastrectomy for gastric cancer. A randomized controlled trial. Ann Surg 2021; 273: 858-867.

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