This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis. A randomized clinical trial. JAMA 2019; 321: 156-164.

Published: 9th April 2019

Authors: Costello SP, Hughes PA, Waters O, Bryant RB, Vincent AD, Blatchford P et al.

Conclusion

The trial included 73 adults with mild to moderate colitis. Faecal transplantation caused steroid-free remission in 32 per cent of treated patients versus 9 per cent in controls. Remission was maintained at 1 year in 42 per cent of the former group.

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Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study. Gut 2018; 67: 2107–2115.

Authors: Halkjær SI, Christensen AH, Lo BZS, Browne PD, Günther S, Hansen LH et al.

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Tranexamic acid for lower GI hemorrhage: a randomized placebo-controlled clinical trial. Dis Colon Rectum 2018; 61: 99-106.

Authors: Smith S, Murray D, Pockney P, Bendinelli C, Draganic B, Carroll R et al.

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Telemedicine for management of inflammatory bowel disease (myIBDcoach): a pragmatic, multicentre, randomized controlled trial. Lancet 2017; 390: 959–968.

Authors: de Jong MJ, van der Meulen-de Jong AE, Romberg-Camps MJ, Becx MC, Maljaars JP, Cilissen M et al.

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Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection. A randomized clinical trial. JAMA 2016; 315: 142-149.

Authors: Lee CH, Steiner T, Petrof EO, Smieja M, Roscoe D, Nematallah A et al. et al.

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Crohn’s disease management after intestinal resection: a randomised trial. Lancet 2015; 385:1406–1417.

Authors: De Cruz P, Kamm MA, Hamilton AL, Ritchie KJ, Krejany EO, Gorelik A et al. et al.

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A prospective, randomized, non-inferiority trial of steroid dosing after major colorectal surgery. Ann Surg 2014; 259: 32-37.

Authors: Zaghiyan K, Melmed GY, Berel D, Ovsepyan G, Murrell Z, Fleshner P et al.

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A randomised phase I study of etrolizumab (rhuMab beta7) in moderate to severe ulcerative colitis. Gut 2013; 62: 1122-1130.

Authors: Rutgeerts PJ, Fedorak RN, Hommes DW, Sturm A, Baumgart DC, Bressler B et al. et al.

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Tofacitinib, an oral janus kinase inhibitor, in active ulcerative colitis. N Engl J Med 2012; 367: 616-624.

Authors: Sandborn WJ, Ghosh S, Panes J, Vranic I, Su C, Rousell S et al. et al.

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Randomized trial of laparoscopically assisted versus open colorectal resection for endometriosis: morbidity, symptoms, quality of life and fertility. Ann Surg 2010; 251: 1018-1023.

Authors: Darai E, Dubernard G, Coutant C, Frey C, Rouzier R, Ballester M. et al.

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Hand-assisted laparoscopic versus open restorative proctocolectomy with ileal pouch anal anastomosis: a randomized trial. Ann Surg 2004; 240: 984-992.

Authors: Maartense S, Dunker MS, Slors JF, Cuesta MA, Gouma DJ, van Deventer SJ et al. et al.

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Prospective, randomized, mulitcenter, controlled trial of a bioartificial liver in treating acute liver failure. Ann Surg 2004; 239: 660-670.

Authors: Demetriou AA, Brown RS Jr, Busuttil RW, Fair J, McGuire B, Rosenthal P et al.

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A randomised trial to assess the safety and efficacy of carbon dioxide versus air insufflation in colonoscopy Gut 2002; 50: 604-7.

Authors: Bretthauer M, Thiis, Evensen E, Huppertz, Hauss G, Gisselsson L et al.