This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of hydroxyethyl starch vs saline for volume replacement therapy on death or postoperative complications among high-risk patients undergoing major abdominal surgery. The FLASH randomized clinical trial. JAMA 2020; 323: 225-236

Published: 20th March 2020

Authors: Futier E, Garot M, Godet T, Biais M, Verzilli D, Ouattara A et al.

Conclusion

A total of 775 patients at risk of kidney injury were randomly allocated starch or saline solution. After 14 days, the risk of death or major complications was similar in the starch (36 per cent) and saline (32 per cent) groups, P= 0.33.

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