This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet 2017; 390: 2779-2789.

Published: 22nd February 2018

Authors: Colombel J-F, Panaccione R, Bossuyt P, Lukas M, Baert F, Vaňásek T et al.

Conclusion

Some 244 patients were included. Those randomized to tight control were more likely to reach the primary endpoint (mucosal healing and no deep ulcers) at six months: 46 versus 30 per cent in the standard clinical management group (P=0.01).

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