Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomized, placebo-controlled trial. Lancet 2019; 394: 1713-1723

Published: 5th March 2020

Authors: The CRASH-3 Trial Collaborators

Conclusion

This study included 12737 patients with a head injury. In those treated within 3h of injury (and not obtunded), tranexamic acid reduced the risk of head injury-related death from 14 to 12.5 per cent, relative risk 0.89, 95 per cent confidence interval 0.8 to 1.0.

Pubmed Link

You may also be interested in

Scientific Surgery

Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet 2018; 392: 283-291.

Authors: Moore HB, Moore EE, Chapman MP, McVaney K, Silliman CC, Banerjee A et al.

Scientific Surgery

Prehospital plasma during air medical transport in trauma patients at risk for hemorrhagic shock. N Engl J Med 2018; 379: 315-326.

Authors: Sperry JS, Guyette FX, Brown JB, Yazer MH, Triulzi DJ, Early-Young BJ et al.

Scientific Surgery

Effect of abdominal ultrasound on clinical care, outcomes, and resource use among children with blunt torso trauma. A randomized clinical trial. JAMA 2017; 317: 2290-2296.

Authors: Holmes JF, Kelley KM, Wootton-Gorges SL, Utter GH, Abramson LP, Rose JS et al.

Scientific Surgery

Randomized controlled trial evaluating the efficacy of peritoneal resuscitation in the management of trauma patients undergoing damage control surgery. J Am Coll Surg 2017; 224: 396–404.

Authors: Smith JW, Matheson PJ, Franklin GA, Harbrecht BG, Richardson DJ, Garrison RN et al.

Scientific Surgery

Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. Lancet 2016; 388: 673-683.

Authors: Sierink JC, Treskes K, Edwards MJR, Beuker BJA, den Hartog D, Hohmann J et al.

Scientific Surgery

Transfusion of cryopreserved packed red blood cells is safe and effective after trauma: a prospective randomized trial. Ann Surg 2015; 262: 426–433.

Authors: Schreiber M, McCully B, Holcomb JB, Robinson BR, Minei JP, Stewart R et al. et al.

Scientific Surgery

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma. The PROPPR randomized clinical trial. JAMA 2015; 313: 471-482.

Authors: Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM et al. et al.

Scientific Surgery

Whole body computed tomographic scanning leads to better survival as opposed to selective scanning in trauma patients: a systematic review and meta-analysis. J Trauma Acute Care Surg 2014; 77: 534-539.

Authors: Caputo ND, Stahmer C, Lim G, Shah K

Scientific Surgery

Results of a prospective randomized controlled study of the use of carboxymethylcellulose sodium hyaluronate adhesion barrier in trauma open abdomens. Surgery 2014; 156: 419-430.

Authors: Stawicki SP, Green JM, Martin ND, Green RH, Cipolla J, Seamon MJ et al. et al.

Scientific Surgery

Saline versus Plasma-lyte in initial resuscitation of trauma patients: a randomized trial. Ann Surg 2014; 259: 255-262.

Authors: Young JB, Utter GH, Schermer CR, Galante J, Phan HH, Yang Y et al. et al.

Scientific Surgery

Safety and efficacy of pharmacologic thromboprophylaxis following blunt head injury: a systematic review. J Trauma Acute Care Surg 2013; 75: 642–656.

Authors: Reeves F, Batty L, Pitt V, Chau M, Pattuwage L, Gruen RL et al.

Scientific Surgery

A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions. Ann Surg 2013; 285: 527–533.

Authors: Cotton BA, Podbielski J, Camp E, Welch T, del Junco D, Bai Y et al. et al.