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Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomized, placebo-controlled trial. Lancet 2019; 394: 1713-1723

Published: 5th March 2020

Authors: The CRASH-3 Trial Collaborators


This study included 12737 patients with a head injury. In those treated within 3h of injury (and not obtunded), tranexamic acid reduced the risk of head injury-related death from 14 to 12.5 per cent, relative risk 0.89, 95 per cent confidence interval 0.8 to 1.0.

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