This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomized, placebo-controlled trial. Lancet 2019; 394: 1713-1723
Published: 5th March 2020
Authors: The CRASH-3 Trial Collaborators
Conclusion
This study included 12737 patients with a head injury. In those treated within 3h of injury (and not obtunded), tranexamic acid reduced the risk of head injury-related death from 14 to 12.5 per cent, relative risk 0.89, 95 per cent confidence interval 0.8 to 1.0.
Pubmed LinkYou may also be interested in
Scientific Surgery
Authors: Guyette FX, Brown JB, Zenati MS, Early-Young BJ, Adams PW, Eastridge BJ et al.
Scientific Surgery
Authors: Arvieux C, Frandon J, Tidadini F, Monnin-Bares V, Foote A, Dubuisson V et al.
Scientific Surgery
Authors: Bulger E, May K, Robinson BR, Evans DC, Henry S, Green J et al.
Scientific Surgery
Authors: Moore HB, Moore EE, Chapman MP, McVaney K, Silliman CC, Banerjee A et al.
Scientific Surgery
Authors: Sperry JS, Guyette FX, Brown JB, Yazer MH, Triulzi DJ, Early-Young BJ et al.
Scientific Surgery
Authors: Holmes JF, Kelley KM, Wootton-Gorges SL, Utter GH, Abramson LP, Rose JS et al.
Scientific Surgery
Authors: Smith JW, Matheson PJ, Franklin GA, Harbrecht BG, Richardson DJ, Garrison RN et al.
Scientific Surgery
Authors: Sierink JC, Treskes K, Edwards MJR, Beuker BJA, den Hartog D, Hohmann J et al.
Scientific Surgery
Authors: Schreiber M, McCully B, Holcomb JB, Robinson BR, Minei JP, Stewart R et al. et al.
Scientific Surgery
Authors: Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM et al. et al.
Scientific Surgery
Authors: Caputo ND, Stahmer C, Lim G, Shah K
Scientific Surgery
Authors: Stawicki SP, Green JM, Martin ND, Green RH, Cipolla J, Seamon MJ et al. et al.