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Efficacy of soluble fibre, antispasmodic drugs and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol 2020; 5: 117-131.

Published: 22nd July 2020

Authors: Black CJ, Yuan Y , Selinger CP, Camilleri CP, Quigley EMM, Moayyedi P et al.


There were 51 RCTs that included 4644 patients. Most studies were short term (up to 12 weeks), and only 13 were at low risk of bias. Peppermint oil was ranked first for global IBS symptoms, and tricyclic antidepressants best for pain.

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