This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Efficacy and safety of alprostadil in patients with peripheral arterial occlusive disease Fontaine stage IV: results of a placebo-controlled randomized multicenter trial (ESPECIAL). Eur J Vasc Endovasc Surg 2017; 53: 559-566.

Published: 2nd August 2017

Authors: Lawall H, Pokrovsky A, Checinski P, Ratushnyuk A, Hamm G, Randerath O et al.

Conclusion

Twice daily alprostadil for four weeks did not affect the rate of complete healing (18.4 per cent versus 17.2 per cent on placebo) or the rate of major amputation (12.6 versus 14.6 per cent, respectively) in this study that included 840 patients.

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