This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Efficacy and safety of aspirin in patients with peripheral vascular disease: an updated systematic review and meta-analysis of randomized controlled trials. PLoS ONE 2017; 12: e0175283.

Published: 22nd February 2018

Authors: Mahmoud AN, Elgendy AY, Rambarat C, Mahtta D, Elgendy IY, Bavry AA et al.

Conclusion

This updated meta-analysis included eleven trials. It cast doubt on the ability of aspirin to reduce all-cause mortality (relative risk: 0.93, 95 per cent confidence interval 0.8 to 1.1) and major cardiac and cerebral vascular events (1, 0.83 to 1.2).

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