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Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2018; 391: 51–58.

Published: 22nd February 2018

Authors: Van Brunschot S, van Grinsven J, van Santvoort HC, Bakker OJ, Besselink MG, Boermeester MA et al.


Ninety-eight patients were randomly assigned to endoscopic drainage followed by endoscopic necrosectomy if indicated, or percutaneous drainage followed by video-assisted retroperitoneal debridement. Rates of death or major complication within six months were similar: 43 versus 45 per cent, respectively; P=0.5. Mortality rates were similar.

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