This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Esomeprazole and aspirin in Barrett’s oesophagus (AspECT): a randomised factorial trial. Lancet 2018; 392: 400–8.

Published: 15th October 2018

Authors: Jankowski JAZ, de Caestecker J, Love SB, Reilly G, Watson P, Sanders S et al.

Conclusion

This multicentre study had a 2 x 2 factorial design and included 2557 patients followed for a median 8.9 years. High-dose esomeprazole with aspirin provided the best protection against death, oesophageal cancer and high-grade dysplasia.

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