This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node negative breast cancer (RAPID): a randomized controlled trial. Lancet 2019; 394: 2165-2172

Published: 5th March 2020

Authors: Whelan TJ, Julian JA, Berrang TS, Kim D-H, Germain I, Nichol AM et al.

Conclusion

This study included 2135 women followed for a median of 8.6 years. Ipsilateral breast cancer recurrence occurred in 3 per cent of women after partial radiotherapy, compared to 2.8 per cent who had whole breast radiotherapy: hazard ratio 1.27, 95 per cent confidence interval 0.84 to 1.91. Toxicity was less after partial radiation, but so was adverse cosmesis.

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