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External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node negative breast cancer (RAPID): a randomized controlled trial. Lancet 2019; 394: 2165-2172

Published: 5th March 2020

Authors: Whelan TJ, Julian JA, Berrang TS, Kim D-H, Germain I, Nichol AM et al.


This study included 2135 women followed for a median of 8.6 years. Ipsilateral breast cancer recurrence occurred in 3 per cent of women after partial radiotherapy, compared to 2.8 per cent who had whole breast radiotherapy: hazard ratio 1.27, 95 per cent confidence interval 0.84 to 1.91. Toxicity was less after partial radiation, but so was adverse cosmesis.

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