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Family history of gastric cancer and Helicobacter pylori treatment. N Engl J Med 2020; 382: 427-436

Published: 20th March 2020

Authors: Choi IJ, Kim CG, Lee JY, Kim Y-I, Kook M-C, Park B et al.


Some 3100 first-degree relatives were screened; 1838 had H. pylori infection and were randomly allocated to eradication therapy. After a median of nine years, people who have eradication therapy were less likely to develop stomach cancer: hazard ratio 0.45, 95 per cent c.i. 0.21 to 0.94, P=0.03. Cancer was more likely if H. pylori was not eradicated.

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