This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Final results of the Sunbelt Melanoma Trial: a multi-institutional prospective randomized phase III study evaluating the role of adjuvant high-dose interferon alfa-2b and completion lymph node dissection for patients staged by sentinel lymph node biopsy. J Clin Oncol 2016; 34: 1079-1086.
Published: 25th August 2016
Authors: McMasters KM, Egger ME, Edwards MJ, Ross MI, Reintgen DS, Noyes RD et al.
Conclusion
There was no advantage in disease-free survival shown here for adjuvant interferon in patients who had a single involved node on sentinel node biopsy. Nor was there any advantage to interferon or lymph node dissection in high risk patients without involved nodes.
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