This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial. Lancet 2005; 366: 818¿824.

Published: 1st January 2005

Authors: Pandya KJ, Morrow GR, Roscoe JA, Zhao H, Hickok JT, Pajon E et al.

Conclusion

This trial compared two different doses of gabapentin and placebo for up to eight weeks. The only significant reduction in hot flushes was seen after use of 900mg/day gabapentin, when flushes were reduced by 49 per cent after four weeks and 46 per cent after eight weeks.

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