This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol 2020; 5: 658-666.

Published: 17th November 2020

Authors: Andreson V, Gschossmann J, Layer P

Conclusion

A total of 443 patients were involved: active treatment was given for eight weeks. A composite endpoint including a 30 per cent improvement in pain relief, and relief of irritable bowel syndrome symptoms, was reached in 34 per cent of treated versus 19 per cent of control patients, P=0.0007.

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