This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Hyperbaric oxygen therapy in the treatment of ischemic lower- extremity ulcers in patients with diabetes: Results of the DAMO2CLES multicenter randomized clinical trial. Diabetes Care 2018; 41: 112-119.
Published: 22nd February 2018
Authors: Santema KT, Stoekenbroek RM, Koelemay MJ, Reekers JA, van Dortmont LM, Oomen A et al.
Conclusion
The use of hyperbaric oxygen did not improve the limb salvage in this study of 120 patients (risk difference 10 per cent, 95% confidence interval -4 to 23 per cent) or amputation-free survival (AFS): 3 per cent, 14 to 21 per cent. Some 35 per cent of patients randomized to hyperbaric oxygen did not complete the protocol; those who did had higher AFS.
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