The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Immediate versus postponed intervention for infected necrotizing pancreatitis. N Engl J Med 2021; 385: 1372-1381.

Published: 9th December 2021

Authors: Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL et al.


In this study that included 104 patients, those randomised to delayed surgery had fewer invasive interventions (mean 2.6 versus 4.4; mean difference 1.8, 95 per cent confidence interval 0.42 to 3.68), but severe complications and mortality rates were similar.

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