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Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials. Lancet 2019; 393: 1440-1452.

Published: 21st June 2019

Authors: Early Breast Cancer Trialists' Collaborative Group (EBCTCG)


Individual patient data were available for 26 trials comprising just under forty thousand women. Dose intense chemotherapy reduced 10-year recurrence rate (28 vs 31 per cent, P<0.0001) and all-cause mortality (22.1 versus 24.8 per cent, P<0.0001).

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