The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Initial laparotomy versus peritoneal drainage in extremely low birthweight infants with surgical necrotizing enterocolitis or isolated intestinal perforation. A multicenter randomized clinical trial. Ann Surg 2021; 274: e370-e380.

Published: 9th December 2021

Authors: Blakely M, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK et al.


In this study that included 310 neonates, death or neurodevelopmental impairment after 18 to 22 months occurred in 69 per cent who had initial laparotomy versus 70 per cent who had drainage.

Pubmed Link