This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective noncardiac surgery. A randomized clinical trial. JAMA Surg 2017; 152: e171505.

Published: 22nd February 2018

Authors: Diener S, Luo X, Lin H-M, Sessler DI, Saager L, Sieber FE et al.

Conclusion

The administration of an infusion of dexmedetomidine in the operating theatre did not reduce the rate of subsequent delirium: 12.2 versus 11.4 per cent with placebo; P=0.94.

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