This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. Lancet 2017; 390: 267–275.

Published: 30th September 2017

Authors: Avidan MS, Maybrier HR, Abdallah AB, Jacobsohn E, Vlisides PE, Pryor KO et al.

Conclusion

Some 672 patients were randomized into two groups at different ketamine doses, and a control group. There was no difference in the rate of postoperative delirium between the combined ketamine group (19.5 per cent) and the control group (19.8 per cent).

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