This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial. BMJ 2018; 363: k3965.

Published: 6th February 2019

Authors: Loozen CS, van Santvoort HC, van Duijvendijk P, Besselink MG, Gouma DJ, Nieuwenhuijzen GA et al.

Conclusion

Some 134 high risk patients with acute cholecystitis were included. One year survival rates were similar, but major complications were much more frequent in the drainage group: 65 versus 12 per cent, P<0.001.

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