This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 2015; 386:1269–1277.
Published: 5th January 2016
Authors: Vennix S, Muster GD, Mulder IM, Swank HA, Consten EC, Belgers EH et al on behalf of the Ladies trial collaborators et al.
Conclusion
This part of the trial was stopped early after 90 patients had been randomized after an increased event rate in the lavage group. The primary endpoint was a composite of major morbidity or mortality within twelve months, and was reached by 30 (67 per cent) of lavage patients and 24 (60 per cent) after sigmoidectomy.
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