This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Lapatinib-related rash and breast cancer outcome in the ALTTO phase III randomized trial. J Natl Cancer Inst 2016; 108: djw037.
Published: 9th November 2016
Authors: Sonnenblick A, de Azambuja E, Agbor-tarh D, Bradbury I, Campbell C, Huang Y et al.
Conclusion
Of 6098 women treated with lapatinib, 1389 (35 per cent) developed an early rash. At median follow-up of 4.5 years, overall survival was significantly better in those who developed the rash: hazard ratio 0.63, 95 per cent confidence interval 0.48 to 0.82, P<0.001.
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