This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Local treatment of unresectable colorectal liver metastases: results of a randomized phase II trial. J Natl Cancer Inst 2017; 109. doi: 10.1093/jnci/djx015.

Published: 5th January 2018

Authors: Ruers T, Van Coevorden F, Punt CJA, Pierie J-PEN, Borel-Rinkes I, Ledermann JA et al.

Conclusion

Some 119 patients with irresectable liver metastasis were offered chemotherapy with, or without radio frequency ablation. After a median of 9.7 years, patients who had radiofrequency had improved overall survival: hazard ratio 0.58, 95 per cent confidence interval 0.38 to 0.88, P=0.01.

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Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial. Gut 2020; 69: 1492-1501.

Authors: Kudo M, Ueshima K, Ikeda M, Torimura T, Tanebe N, Aikata H et al.

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Adjuvant 131I-metuximab for hepatocellular carcinoma after liver resection: a randomised, controlled, multicentre, open-label, phase 2 trial. Lancet Gastroenterol Hepatol 2020; 5: 548-560.

Authors: Li J, Xing J, Yang Y, Liu J, Wang W, Xia Y et al.

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Antiviral therapy reduces hepatocellular carcinoma recurrence in patients with low HBV-DNA levels. A randomized controlled trial. Ann Surg 2018: 268: 943-954.

Authors: Huang G, Li P-P, Lau WY, Pan Z-Y, Zhao L-H, Wang Z-G et al.

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Radiofrequency ablation using a 10‐mm target margin for small hepatocellular carcinoma in patients with liver cirrhosis: A prospective randomized trial. J Surg Oncol 2017; 115: 971-979.

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Fibrin sealant patch (TachoSil) vs oxidized regenerated cellulose patch (Surgicel Original) for the secondary treatment of local bleeding in patients undergoing hepatic resection: a randomized controlled trial. J Am Coll Surg 2012; 222: 261-268.

Authors: Genyk Y, Kato T, Pomposelli JJ, Wright Jr JK, Sher LS, Tetens V et al.

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Fibrin sealant with polyglycolic acid felt vs fibrinogen-based collagen fleece at the liver cut surface for prevention of postoperative bile leakage and hemorrhage: a prospective, randomized, controlled study. J Am Coll Surg 2016; 222: 59-64.

Authors: Kobayashi S, Takeda Y, Nakahira S, Tsujie M, Shimizu J, Miyamoto A et al.

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Antiviral therapy improves postoperative survival in patients with hepatocellular carcinoma: a randomized controlled trial. Ann Surg 2015; 261: 56-66.

Authors: Huang G, Lau WY, Wang Z-G, Pan Z-Y, Yuan S-X, Feng S et al. et al.

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Adjuvant radiotherapy in centrally located hepatocellular carcinomas after hepatectomy with narrow margin (<1cm): a prospective randomized study. J Am Coll Surg 2014; 218: 381-392.

Authors: Yu W, Wang W, Rong W, Wang L, Xu Q, Wu F et al. et al.

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Adjuvant hepatic intra-arterial iodine 131- lipiodol following curative resection of hepatocellular carcinoma: a prospective randomized trial. World J Surg 2013; 37: 1356-1361.

Authors: Chung AY, Ooi LL, Machin D, Tan SB, Goh BK, Wong JS et al. et al.

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Radiofrequency ablation with or without transcatheter chemoembolization in the treatment of hepatocellular carcinoma: a prospective randomized trial. J Clin Oncol 2013; 31: 426-432.

Authors: Peng Z-W, Zhang Y-J, Chen M-S, Xu L, Lian H-L, Lin X-J et al. et al.

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Effects of pentoxifylline on liver regeneration: a double blinded, randomized clinical trial in 101 patients undergoing major liver resection. Ann Surg 2010; 252: 813-822.

Authors: Petrowsky H, Breitenstein S, Slankamenac K, Vetter D, Lechmann K, Heinrich S et al. et al.

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A prospective randomized controlled trial of preoperative transarterial chemoembolisation for resectable large hepatocellular carcinoma Ann Surg 2009; 249: 195-202

Authors: Zhou W-P, Lai ECH, Li A-J, Fu S-Y, Zhou J-Ppan Z-y et al