The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma. The NEOCRTEC5010 randomized clinical trial. JAMA Surg 2021; 156: 721-729.

Published: 9th December 2021

Authors: Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z et al.


This study included 451 patients, with median follow-up 53.5 months. Neoadjuvant treatment improved five year survival from 49.1 to 59.9 per cent, P=0.03.

Pubmed Link