This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma. The NEOCRTEC5010 randomized clinical trial. JAMA Surg 2021; 156: 721-729.
Published: 9th December 2021
Authors: Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z et al.
This study included 451 patients, with median follow-up 53.5 months. Neoadjuvant treatment improved five year survival from 49.1 to 59.9 per cent, P=0.03.Pubmed Link
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Intrathoracic vs cervical anastomosis after totally or hybrid minimally invasive esophagectomy for esophageal cancer. A randomized clinical trial. JAMA Surg 2021; 156: 601-610.
Authors: Van Workum F, Verstegen MHP, Klarenbeek BR, Bouwense SAW, van Berge Henegouwen MI, Daams F et al.
Five-year survival outcomes of hybrid minimally invasive esophagectomy in esophageal cancer. Results of the MIRO Randomized Clinical Trial. JAMA Surg 2021; 156: 323-332.
Authors: Nuytens F, Dabakuyo-Yonli TS, Meunier B, Gagnière J, Collet D, D’Journo XB et al.
Randomized comparison of gastric tube reconstruction with and without duodenal diversion plus Roux-en-Y anastomosis after esophagectomy. Ann Surg 2020; 272: 48-54.
Authors: Yano M, Sugimura K, Miyata H, Motoori M, Tanaka K, Omori T et al.
Health-related quality of life following hybrid minimally invasive versus open esophagectomy for patients with esophageal cancer. Analysis of a multicenter, open-label, randomized phase III controlled trial. The MIRO Trial. Ann Surg 2020; 271: 1023-1029.
Authors: Mariette C, Markar S, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al.
Survival outcomes after laparoscopy-assisted distal gastrectomy versus open gastrectomy with nodal dissection for clinical stage 1A or 1B gastric cancer (JCOG0912): a multicenter, non-inferiority, phase 3 randomised controlled trial. Lancet Gastroenterol Hepatol 2020; 5: 142-151
Authors: Katai H, Mizusawa J, Katayama H, Morita S, Yamada T, Brando E et al.
Direct oral feeding following minimally invasive esophagectomy (NUTRIENT II trial). An international, multicenter, open-label randomized controlled trial. Ann Surg 2020; 271: 41-47
Authors: Berkelmans GH, Fransen LFC, Dolmans-Zwartjes ACP, Kouwenhoven EA, van Det MJ, Nilsson M et al.
Short-term outcomes of a multicenter randomized controlled trial comparing laparoscopic distal gastrectomy with D2 lymphadenectomy to open distal gastrectomy for locally advanced gastric cancer (KLASS-02-RCT). Ann Surg 20129; 270: 983-991
Authors: Lee H-J, Hyung WJ, Yang H-K, Han S, Park Y-K, An JY et al.
Combined surgery and extensive intraoperative peritoneal lavage vs surgery alone for treatment of locally advanced gastric cancer. The SEIPLUS randomized clinical trial. JAMA Surg 2019; 154: 610-616
Authors: Guo J, Xu A, Sun X, Zhao X, Xia Y, Rao H et al.
Robot-assisted minimally invasive thoracolaparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer. A randomized controlled trial. Ann Surg 2019; 269: 621-630.
Authors: van der Sluis PC, van der Horst S, May AM, Schippers C, Brosens L, Joore HC et al.
Authors: Mariette C, Markar SR, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D et al.
Early oral feeding following McKeown minimally invasive esophagectomy: an open-label, randomized, controlled, noninferiority trial. Ann Surg 2018; 267: 435-442.
Authors: Sun H-B, Li Y, Liu X-B, Zhang R-X, Wang Z-F, Lerut T et al.
Circular stapling versus triangulating stapling for the cervical esophagogastric anastomosis after esophagectomy in patients with thoracic esophageal cancer: A prospective, randomized, controlled trial. Surgery 2017; 162: 131-138.
Authors: Hayata K, Nakamori M, Nakamura M, Ojima T, Iwahashi M, Katsuda M et al.