This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Long-term update of US GI Intergroup RTOG 98-11 phase III trial for anal carcinoma: survival, relapse, and colostomy failure with concurrent chemoradiation involving fluorouracil/mitomycin versus fluorouracil/cisplatin. J Clin Oncol 2012; 30: 4344–4351.
Published: 16th April 2013
Authors: Gunderson LL, Winter KA, Ajani JA, Pedersen JE, Moughan J, Benson III AB et al.
Conclusion
This study included 649 patients that could be analysed after five years. The flurouracil and mitomycin combination improved disease-free (68 versus 58 per cent, P=0.006) and overall survival (78 versus 71 per cent, P=0.026).
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