This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A mechanistic multicentre, parallel group randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D). Gut 2016; 65: 91-99.

Published: 20th July 2016

Authors: Lam C, Tan W, Leighton M, Hastings M, Lingaya M, Falcone Y et al.

Conclusion

A total of 136 patients with irritable bowel syndrome were included and treated for 12 weeks. Daily stool frequency rates were similar with mesalazine (mean 2.8) and placebo (2.7). Nor did mesalazine improve abdominal pain.

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