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Meta-analysis, meta-regression, and GRADE assessment of randomized and nonrandomized studies of incisional negative pressure wound therapy versus control dressings for the prevention of postoperative wound complications. Ann Surg 2020; 272: 81-91.

Published: 15th October 2020

Authors: Zwanenburg P, Tol BT, Obdeijn MC, Lapid O, Gans SL, Boermeester MA et al.


There were 28 RCTs involving 4398 procedures. Negative pressure dressings reduced the rate of surgical site infection (relative risk 0.61, 95 per cent confidence interval 0.49 to 0.76, P<0.0001), wound dehiscence (0.78, 0.64 to 0.94) and seroma (0.43, 0.32 to 059).

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