This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Methylprednisolone therapy in deceased donors reduces inflammation in the donor liver and improves outcome after liver transplantation: a prospective randomised controlled trial Ann Surg 2008; 248: 1042¿50

Published: 1st January 2008

Authors: Kotsch K, Ulrich F, Reutzel-Selke A, Pascher A, Faber WW, Hoffman S et al et al.

Conclusion

Steroids were given intravenously from the time consent was given to the time of organ recovery. In this study that included 100 deceased donors, the steroid ameliorated the ischaemia reperfusion injury after liver transplantation, and reduced the rate of acute rejection

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