The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Morbidity and mortality of patients who underwent minimally invasive esophagectomy after neoadjuvant chemo-radiotherapy vs neoadjuvant chemotherapy for locally advanced esophageal squamous cell carcinoma. A randomized clinical trial. JAMA Surg 2021; 156: 444-451.

Published: 24th November 2021

Authors: Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y et al.


The addition of radiotherapy to neoadjuvant chemotherapy was tested in this study that included 264 patients. There was no difference in perioperative morbidity or mortality. Additional radiotherapy improved the complete pathological response rate (35.7 versus 3.8 per cent, P<0.001) and the rate of negative lymph nodes (66.1 versus 46.2 per cent, P=0.03), but did not improve one year survival.

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