This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis. Lancet Gastro Hepatol 2021; 9: 733-742.
Published: 9th December 2021
Authors: Akshintala VS, Weiland CJS, Bhullar FA, Kamal A, Kanthasamy K, Kuo A et al.
Some 55 RCTs were included that studied 17 062 patients. The rate of pancreatitis was 12.2 per cent in controls, and was reduced significantly by Intravenous fluids and non steroidal drugs, and stents. Rectal diclofenac was the most effective non steroidal.Pubmed Link
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Immediate versus postponed intervention for infected necrotizing pancreatitis. N Engl J Med 2021; 385: 1372-1381.
Authors: Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL et al.
Immediate oral refeeding in patients with mild and moderate acute pancreatitis. A multicenter, randomized controlled trial (PADI trial). Ann Surg 2021; 274: 255-263.
Authors: Ramírez-Maldonado E, Gordo SL, Pueyo EM, Sánchez-García A, Mayol S, González S et al.
Treatment for Infected pancreatic necrosis should be delayed, possibly avoiding an open surgical approach. A systematic review and network meta-analysis. Ann Surg 2021; 273: 251-257.
Authors: Ricci C, Pagano N, Ingaldi C, Frazzoni L, Migliori M, Alberici L et al.
Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial. Lancet 2020; 396: 167-176.
Authors: Schepers NJ, Hallensleben NDL, Besselink MG, Anten M-PG, Bollen TL, da Costa DW et al.
Effect of early surgery vs endoscopy-first approach on pain in patients with chronic pancreatitis. The ESCAPE randomized clinical trial. JAMA 2020; 323: 237-247
Authors: Issa Y, Kempeneers MA, Bruno MJ, Fockens P, Poley J-W, Ali UA et al.
Gallstone pancreatitis: admission versus normal cholecystectomy—a randomized trial (Gallstone PANC Trial). Ann Surg 2019; 270: 519-527
Authors: Mueck K, Wei S , Pedroza C , Bernardi K , Jackson ML , Liang MK et al.
Authors: Van Dijk SM, Hallensleben NDL, van Santvoort HC, Fockens P, van Goor H, Bruno MJ et al.
Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2018; 391: 51–58.
Authors: Van Brunschot S, van Grinsven J, van Santvoort HC, Bakker OJ, Besselink MG, Boermeester MA et al.
Can laparoscopic cholecystectomy prevent recurrent idiopathic acute pancreatitis? A prospective randomized multicenter trial. Ann Surg 2015; 262: 736–741.
Authors: Räty S, Pulkkinen J, Nordback I, Sand J, Victorzon M, Grönroos J et al. et al.
Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial. Lancet 2015; 386: 1261–1268.
Authors: Da Costa DW, Bouwense SA, Schepers NJ, Besselink MG, van Santvoort HC, van Brunschot S et al for the Dutch Pancreatitis Study Group et al.
Synbiotics in surgery for chronic pancreatitis: are they truly effective? A single-blind prospective randomized control trial. Ann Surg 2015; 262: 31-37.
Authors: Rammohan A, Sathyanesan J, Rajendran K, Pitchaimuthu A, Perumal S, Balaraman K et al. et al.
Early versus on-demand nasoenteric tube feeding in acute pancreatitis. N Engl J Med 2014; 371: 1983-1993.
Authors: Bakkar OJ, van Brunschot S, van Santvoort HC, Besselink MG, Bollen TL, Boermeester MA et al. et al.