The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

One vs. three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA 2012; 307: 1265-1272.

Published: 16th October 2012

Authors: Joensuu H, Eriksson M, Sundby HK, Hartmann JT, Pink D, Schutte J et al. et al.

Conclusion

In this study that included 400 patients, a quarter of those randomized to the longer course of imatinib failed to complete the treatment. Overall five year survival was improved in the three year group from 81.7 to 92 per cent, hazard ratio 0.45, 95 per cent confidence interval 0.22 to 0.89, P=0.02.

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