This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Outcomes after angiography with sodium bicarbonate and acetylcysteine. N Engl J Med 2018; 378: 603-614.

Published: 17th May 2018

Authors: Weisbord SD, Gallagher M, Jneid H, Garcia S, Cass A, Thwin S-S et al.

Conclusion

This 2x2 factorial trial that included 5177 patients concluded that neither five days of oral acetylcysteine (4.6 per cent) nor intravenous sodium bicarbonate (4.4 per cent) reduced acute kidney injury compared to standard hydration with 0.9 per cent sodium chloride alone (4.7 per cent).

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