The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial Lancet 2020; 396: 1653-1662.

Published: 19th March 2021

Authors: Jochmans I, Brat A, Davies L, Hofker HS, van de Leemkolk FEM, Leuvenink HGD et al.


Paired donor kidneys were randomised to one of each perfusion method; 106 pairs were included. Mean eGFR was similar in both groups after 12 months (50.5 mL/min in oxygenated versus 46.7 mL/min in cold perfused kidneys). Severe complications were fewer for oxygenated kidneys (11 versus 16 per cent; P=0.032), as was graft failure (3 versus 10 per cent, P=0.028).

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