This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Paclitaxel with inhibitor of apoptosis antagonist, LCL161, for localized triple-negative breast cancer, prospectively stratified by gene signature in a biomarker-driven neoadjuvant trial. J Clin Oncol 2018; 36: 3126-3133.
Published: 22nd March 2019
Authors: Bardia A, Parton M, Kummel S, Estevez LG, Huang C-S, Cortes J et al.
Conclusion
Of 209 enrolled women, 32 per cent were gene signature (GS) negative. Pathological complete response was higher in the active arm in GS positive tumours (38 versus 17 per cent), but similarly poor in GS negative tumours.
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