This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Partial lateral internal sphincterotomy versus combined botulinum toxin A Injection and topical diltiazem in the treatment of chronic anal fissure: a randomized clinical trial. Dis Colon Rectum 2015; 58: 228-234.
Published: 23rd June 2015
Authors: Gandomkar H, Zeinoddini A, Heidari R, Amoli H
Conclusion
Overall healing was better after sphincterotomy (94%) than botulinum and diltiazem (65%; P<0.001) in this study that included 99 patients. Surgery was particularly beneficial in patients who had a fissure for over a year. Incontinence scores, however, were higher after surgery (P=0.04).
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