This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III Trial. J Clin Oncol 2011; 29: 1715–1721.

Published: 7th July 2011

Authors: Ychou M, Boige V, Pignon J-P, Conroy T, Bouche O, Lebreton G et al. et al.

Conclusion

Some 224 patients were included in the study. Chemotherapy improved five year disease-free survival from 19 to 34 per cent: hazard ratio 0.65, 95 per cent confidence interval 0.48 to 0.89, P=0.003; and overall survival from 24 to 38 per cent (0.69, 0.5 to 0.95, P=0.02).

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A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

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