The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for respectable liver metastases from colorectal cancer (EORTC Intergroup Trial 40983): a randomised controlled trial. Lancet 2008; 371: 1007-1016.

Published: 1st January 2008

Authors: Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P et al.

Conclusion

A total of 364 patients with up to four liver metastases were randomly allocated six cycles of chemotherapy before, and six cycles after their liver surgery. After three years, progression-free survival was improved in the chemotherapy group: 35.4 vs. 28.1 per cent, P=0.058.



 

Pubmed Link

You may also be interested in

Scientific Surgery

Non-steroidal anti-inflammatory drugs, intravenous fluids, pancreatic stents, or their combinations for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and network meta-analysis. Lancet Gastro Hepatol 2021; 9: 733-742.

Authors: Akshintala VS, Weiland CJS, Bhullar FA, Kamal A, Kanthasamy K, Kuo A et al.

Scientific Surgery

Immediate versus postponed intervention for infected necrotizing pancreatitis. N Engl J Med 2021; 385: 1372-1381.

Authors: Boxhoorn L, van Dijk SM, van Grinsven J, Verdonk RC, Boermeester MA, Bollen TL et al.

Scientific Surgery

Immediate oral refeeding in patients with mild and moderate acute pancreatitis. A multicenter, randomized controlled trial (PADI trial). Ann Surg 2021; 274: 255-263.

Authors: Ramírez-Maldonado E, Gordo SL, Pueyo EM, Sánchez-García A, Mayol S, González S et al.

Scientific Surgery

Safety of combined division vs separate division of the splenic vein in patients undergoing distal pancreatectomy. A noninferiority randomized clinical trial. JAMA Surg 2021; 156: 418-428.

Authors: Yamada S, Fujii T, Sonohara F, Kawai M, Shibuya K, Matsumoto I et al.

Scientific Surgery

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 438-447.

Authors: Wang M, Li D, Chen R, Huang X, Li J, Liu Y et al.

Scientific Surgery

Anterior approach vs conventional hepatectomy for resection of colorectal liver metastasis. A randomized clinical trial. JAMA Surg 2021; 156: 31-40.

Authors: Rahbari NN, Birgin E, Bork U, Mehrabi A, Reißfelder C, Weitz J et al.

Scientific Surgery

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial. Gut 2020; 69: 1492-1501.

Authors: Kudo M, Ueshima K, Ikeda M, Torimura T, Tanebe N, Aikata H et al.

Scientific Surgery

Drain placement after uncomplicated hepatic resection increases severe postoperative complication rate. A Japanese multi-institutional randomized controlled trial (ND-trial). Ann Surg 2021; 273: 224-231.

Authors: Arita J, Sakamaki K, Saiura A, Konishi M, Sakamoto Y, Hashimoto M et al.

Scientific Surgery

Nasogastric decompression vs no decompression after pancreaticoduodenectomy. The randomized clinical IPOD Trial. JAMA Surg 2020; 155: e202291.

Authors: Bergeat D, Merdrignac A, Robin F, Gaignard E, Rayar M, Meunier B et al.

Scientific Surgery

Pancreatoduodenectomy with epidural vs patient-controlled intravenous analgesia. A randomized clinical trial. JAMA Surg 2020; 155: e200794.

Authors: Klotz R, Larmann J, Klose C, Bruckner T, Benner L, Doerr-Harim C et al.

Scientific Surgery

Treatment for Infected pancreatic necrosis should be delayed, possibly avoiding an open surgical approach. A systematic review and network meta-analysis. Ann Surg 2021; 273: 251-257.

Authors: Ricci C, Pagano N, Ingaldi C, Frazzoni L, Migliori M, Alberici L et al.

Scientific Surgery

Simultaneous versus delayed resection for initially resectable synchronous colorectal cancer liver metastases. A prospective, open-label, randomized, controlled trial. Ann Surg 2021; 273: 49-56.

Authors: Boudjema K, Locher C, Sabbagh C, Ortega-Deballon P, Heyd B, Bachellier P et al.