This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Perioperative FOLFOX 4 versus FOLFOX 4 plus Cetuximab versus immediate surgery for high-risk stage II and III colon cancers. A phase II multicenter randomized controlled trial (PRODIGE 22). Ann Surg 2020; 271: 637-645

Published: 15th June 2020

Authors: Karoui M, Rullier A, Piessen G, Legoux JL, Barbier E, De Chaisemartin C et al.

Conclusion

Some 120 patients were randomized to preoperative or perioperative chemotherapy. Perioperative chemotherapy was feasible and tolerable, but did not improve major pathological response rate. It did induce pathological regression and downstaging.

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A randomized Phase II trial of adjuvant hepatic arterial infusion and systemic therapy with or without panitumumab after hepatic resection of KRAS wild-type colorectal cancer. Ann Surg 2021; 274: 248-254.

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Preoperative hepatic and regional arterial chemotherapy in patients who underwent curative colorectal cancer resection. A prospective, multi-center, randomized controlled trial. Ann Surg 2021; 273: 1066-1075.

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Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol 2020; 21: 1620-1629.

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Does a longer waiting period after neoadjuvant radio-chemotherapy improve the oncological prognosis of rectal cancer? Three years’ follow-up results of the Greccar-6 randomized multicenter trial. Ann Surg 2019; 270: 747-754

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A randomized control trial of preoperative oral antibiotics as adjunct therapy to systemic antibiotics for preventing surgical site infection in clean contaminated, contaminated, and dirty type of colorectal surgeries. Dis Colon Rectum 2017; 60: 1291-1298.

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