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Perioperative FOLFOX 4 versus FOLFOX 4 plus Cetuximab versus immediate surgery for high-risk stage II and III colon cancers. A phase II multicenter randomized controlled trial (PRODIGE 22). Ann Surg 2020; 271: 637-645

Published: 15th June 2020

Authors: Karoui M, Rullier A, Piessen G, Legoux JL, Barbier E, De Chaisemartin C et al.


Some 120 patients were randomized to preoperative or perioperative chemotherapy. Perioperative chemotherapy was feasible and tolerable, but did not improve major pathological response rate. It did induce pathological regression and downstaging.

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