This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Perioperative hydrocortisone reduces major complications after pancreaticoduodenectomy: a randomized controlled trial. Ann Surg 2016; 264: 696-702.

Published: 20th December 2016

Authors: Laaninen M, Sand J, Nordback I, Vasama K, Laukkarinen J

Conclusion

This study included 155 patients all of whom received hydrocortisone (HC) at anaesthetic induction, but only patients with fewer than 40% acini on frozen section of the pancreas (n=62) were randomized to continue. Three days of HC postoperatively significantly reduced overall complications: 18 versus 41 percent, P<0.05.

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