This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Perioperative simvastatin therapy in major colorectal surgery: a prospective, double-blind randomized controlled trial. J Am Coll Surg 2016 223: 308–320.
Published: 20th December 2016
Authors: Singh PP, Lemanu DP, Soop M, Bissett IP, Harrison J, Hill AG et al.
Conclusion
Simvastatin reduced plasma concentration of inflammatory markers in the study of 132 procedures, but did not reduce the risk of postoperative complications: odds ratio 0.71, 0.33 to 1.52, P= 0.44.
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