This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Perioperative systemic therapy vs cytoreductive surgery and hyperthermic intraperitoneal chemotherapy alone for resectable colorectal peritoneal metastases. A phase 2 randomized clinical trial. JAMA Surg 2021; 156: 710-720.

Published: 9th December 2021

Authors: Rovers KP, Bakkers C, Nienhuijs SW, Burger JWA, Creemers G-JM, Thijs AMJ et al.

Conclusion

This study included 79 patients. The rate of macroscopic complete treatment was similar in the two groups (89 per cent experimental group versus 86 per cent in controls), and major morbidity rates were similar.

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Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): 10-year follow-up of an open-label, non-inferiority, randomised controlled trial. Lancet Gastro Hepatol 2021; 6: 569-577.

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Colonic J-pouch or straight colorectal reconstruction after low anterior resection for rectal cancer: impact on quality of life and bowel function: a multicenter prospective randomized study. Dis Colon Rectum 2020; 63: 1511-1523.

Authors: Gavaruzzi T, Pace U, Giandomenico F, Pucciarelli S, Bianco F, Selvaggi F et al.

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Meta-analysis and trial sequential analysis of randomized controlled trials comparing high and low ligation of the inferior mesenteric artery in rectal cancer surgery. Dis Colon Rectum 2020; 63: 988-999.

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Two-stage Turnbull-Cutait pull-through coloanal anastomosis for low rectal cancer. A randomized clinical trial. JAMA Surg 2020; 155: e201625.

Authors: Biondo S, Trenti L, Espin E, Bianco F, Barrios O, Falato A et al.

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Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial. Lancet Gastroenterol Hepatol 2020; 5: 465-474.

Authors: Rullier E, Vendrely V, Rouanet P, Tuech JJ, Valverde A

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Low ligation of inferior mesenteric artery in laparoscopic anterior resection for rectal cancer reduces genitourinary dysfunction. Results from a randomized controlled trial (HIGHLOW Trial). Ann Surg 2019; 269: 1018-1024.

Authors: Mari G, Crippa J, Cocozza E, Berselli M, Livraghi L, Carzaniga P et al.

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Laparoscopic versus open resection for rectal cancer. A non-inferiority meta-analysis of quality of surgical resection outcomes. Ann Surg 2019; 269: 849-855.

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Clinical outcome after rectal replacement with side-to-end, colon-J-pouch, or straight colorectal anastomosis following total mesorectal excision. A Swiss Prospective, Randomized, Multicenter Trial (SAKK 40/04). Ann Surg 2019; 269: 827-835.

Authors: Marti W, Curti G, Wehrli H, Grieder F, Graf M, Gloor B et al.

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Better function with a colonic J-pouch or a side-to-end anastomosis? A randomized controlled trial to compare the complications, functional outcome, and quality of life in patients with low rectal cancer after a J-pouch or a side-to-end anastomosis. Ann Surg 2019; 269: 815-826.

Authors: Parc Y, Ruppert R, Fuerst A, Golcher H, Zutshi M, Hull T et al.

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A meta-analysis of randomized controlled trials on the use of suction drains following rectal surgery. Dig Surg 2018; 35: 482–490.

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Robotic versus laparoscopic minimally invasive surgery for rectal cancer: a systematic review and meta-analysis of randomized controlled trials. Ann Surg 2018; 267: 1034-1046.

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Tattooing improves the detection of small lymph nodes and increases the number of retrieved lymph nodes in patients with rectal cancer who receive preoperative chemoradiotherapy: a randomized controlled clinical trial. Am J Surg 2018; 215: 563-569.

Authors: Okada K, Sahahiro S, Ogimi T, Miyakita H, Saito G, Tanaka A et al.