The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Perioperative systemic therapy vs cytoreductive surgery and hyperthermic intraperitoneal chemotherapy alone for resectable colorectal peritoneal metastases. A phase 2 randomized clinical trial. JAMA Surg 2021; 156: 710-720.

Published: 9th December 2021

Authors: Rovers KP, Bakkers C, Nienhuijs SW, Burger JWA, Creemers G-JM, Thijs AMJ et al.


This study included 79 patients. The rate of macroscopic complete treatment was similar in the two groups (89 per cent experimental group versus 86 per cent in controls), and major morbidity rates were similar.

Pubmed Link