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Pharmacomechanical catheter-directed thrombolysis for deep-vein thrombosis. N Engl J Med 2017; 377: 2240-2252.

Published: 25th January 2018

Authors: Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ et al.


The study included 692 patients with proximal DVT. The rate of subsequent post thrombotic syndrome between six and 24 months after treatment was 47 per cent after thrombolysis and 48 per cent after anticoagulation alone. Major bleeding was more common after thrombolysis: 1.7 versus 0.3 per cent, P=0.049.

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