This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Phase III randomized study of 4 weeks of high-dose interferon-α-2b in stage T2bNO, T3a-bNO, T4a-bNO, and T1-4N1a-2a (microscopic) melanoma: a trial of the Eastern Cooperative Oncology Group–American College of Radiology Imaging Network Cancer Research Group (E1697). J Clin Oncol 2017; 35: 885-892.
Published: 26th April 2017
Authors: Agarwala SS, Lee SJ, Yip W, Rao UN, Tarhini AA, Cohen GI et al.
Conclusion
Four weeks of interferon did not improve relapse-free survival after a five years (70 per cent in both groups), or overall survival (both 83 per cent) in this study that included 1150 patients. Quality of life was worse in treated patients.
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