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Phase III randomized trial of bisphosphonates as adjuvant therapy in breast cancer: S0307. J Natl Cancer Inst 2020; 112: 698-707.

Published: 16th September 2020

Authors: Gralow JR, Barlow WE, Paterson AHG, M’iao JL, Lew DL, Stopeck AT et al.


Three different biphosphonate regimens were tested in this trial that included 6097 women. Intravenous zoledronic acid, oral clodronate and oral ibandronate were similar in effect, with no differences between the groups in quality of life, survival and site of metastasis.

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