The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med 2016; 374: 1321-1331.

Published: 15th June 2016

Authors: Kernan WN, Viscoli CM, Furie KM, Young LH, Inzucchi SE, Gorman M et al.

Conclusion

Some 3876 patients with insulin resistance, but not frankly diabetic, were included. Pioglitazone 45m daily reduced the risk of subsequent stroke or myocardial infarction up to a median 4.8 years from 11.8 per cent with placebo to 9 per cent, P=0.007.

Pubmed Link